Role of insulin and counter-regulatory hormones in the control of hepatic glycerolipid synthesis and low-density-lipoprotein catabolism in diabetes.
نویسندگان
چکیده
DAVID N. BRINDLEY,* NICHOLAS F. BROWN,* ANDREW M. SALTER,t SYLVIA C. FISHER? and ROBIN FEARS$ *Lipid and Lipoprotein Research Group arid Department of Biochemistry, Faculty of Medicine, University of Alberta, Edmonton, T6G 2C2, Canada, t Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG72UH, U. K., and Weecham Pharmaceuticals, Biosciences Research Centre, Great Burgh, Yew Tree Bottom Road, Epsom, Surrey K185XQ, U.K.
منابع مشابه
The Effect of Eight Weeks of High-intensity Interval Training on Lipoprotein-associated Phospholipase A2 and Lipid Profile in a Male Rat Model of Type 2 Diabetes
Introduction: Type 2 diabetes (T2D) causes hyperglycemia, hyperinsulinemia, and dyslipidemia, which are all risk factors for atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) has been recognized as an indicator of atherosclerosis due to its role in vessel inflammation. This study aimed to investigate the effect of high-intensity interval training (HIIT) on serum levels of Lp-PL...
متن کاملEffect of Extracts of Cloves (Syzygium Aromaticum) on Hepatic Cell Damage and Oxidative Stress Caused by Diabetes in Adult Rats
Aims: In this study, we investigated the effect of clove extract (Syzygium aromaticum) on liver cell damage and oxidative stress caused by diabetes in adult rats. Methods & Materials: For this study, 28 female rats were collected and divided into four groups: A: Control group; B: Diabetic Control group (DC) which received 20% glycerol dissolved in normal saline as carriers; C: Diabetic rats (D...
متن کاملCorrelation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen receptor (AR) and the enzyme 5-alpha reductase (5αR). Therefore, this study aimed to investigate the relationship between these factors in T2DM. Materials and Methods: This case-co...
متن کاملLipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism.
Growing evidence links the three mammalian lipin proteins, i.e., lipin-1, lipin-2 and lipin-3, to metabolic and cardiovascular diseases such as noninsulin-dependent diabetes mellitus and atherosclerosis. Lipin proteins play a dual function in lipid metabolism by acting as phosphatidate phosphatase (PAP) enzymes and as transcriptional regulators. Genetic variants within the human LPIN1 and LPIN2...
متن کاملMolecular mechanisms involved in hepatic steatosis and insulin resistance
Increased hepatic lipid content is associated with hepatic as well as whole-body insulin resistance and is typical for individuals with type 2 diabetes mellitus. However, whether insulin resistance causes hepatic steatosis or whether hepatic steatosis per se reduces insulin sensitivity remains unclear. Multiple metabolic pathways lead to the development of hepatic steatosis, including enhanced ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Biochemical Society transactions
دوره 17 1 شماره
صفحات -
تاریخ انتشار 1989